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Exclusion of older adults and immunocompromised  individuals in influenza, pneumococcal and COVID-19 vaccine trials before and after the COVID-19 pandemic
CONCLUSIONS: During the COVID-19 pandemic, we found a decrease in the exclusion of older adults from vaccine trials but no significant change in the inclusion of immunocompromised individulas.PMID:37027085 | PMC:PMC10080508 | DOI:10.1007/s40520-023-02380-4
Source: Aging Clinical and Experimental Research - April 7, 2023 Category: Geriatrics Authors: Katrine Bukan Toby Pearce-Slade Mads Eiberg Marco Tinelli Dafna Yahav Jose Tuells Olivier Epaulard Jon G Holler Casper Roed Christian S øborg Jens-Ulrik St æhr Jensen Zitta Barrella Harboe Source Type: research

A Mini Review on Discovery and Synthesis of Remdesivir as an Effective and Promising Drug against COVID-19
Russ J Bioorg Chem. 2021;47(3):609-621. doi: 10.1134/S1068162021030183. Epub 2021 Jun 11.ABSTRACTThe severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as a new human coronavirus has begun spreading over Wuhan City/China in December 2019, and then spread rapidly worldwide, causing pneumonia called COVID-19. Up to now, the scientists have extensively attempted to find effective vaccines and drugs for treatment of coronavirus infections. To this end, various pharmaceutical agents are undergoing the clinical studies to assess their potency and efficacy against COVID-19. Based on the new findings, the U.S. food and d...
Source: Bioorganic Chemistry - June 21, 2021 Category: Chemistry Authors: E Zarenezhad S Behrouz M Farjam M N Soltani Rad Source Type: research